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Siemens 463V FA User Manual

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Copyright © Siemens AG 2010. All rights reserved.
Emerging MRI Techniques for
Abdominal and Pelvic Imaging
Brian M. Dale, PhD
Page 2
Sep-2010
Copyright © Siemens AG 2010
H CSG MR R&DBrian M. Dale, PhD
Background
PhD in Biomedical Engineering – 2004
Case Western Reserve University
Cleveland, OH
Sequence programming
Optimal design
Collaboration Manager
Siemens Healthcare
Cary, NC
IDEA and Physics Team
Abdominal MRI at 3 T
Page 3
Sep-2010
Copyright © Siemens AG 2010
H CSG MR R&DBrian M. Dale, PhD
Outline
Hepatic fat quantification
Abdominal workflow
MRI of the female pelvis
Cancer characterization with 4D imaging
Will not cover in depth
FDA constraints
Overlap with Dr. Lin
References
Fritz-Hansen T, Rostrup E, et al. MRM. 1996 Aug; 36(2):225-31,
Rijpkema M, Kaanders JHAM, et al. JMRI 2001; 14: 457-463.
Parker GJ, Jackson A, et al. In: Proc. ISMRM, 2003. p 1264.
Parker GJ, Roberts C, et al. MRM. 2006 Nov;56(5):993-1000.
Page 4
Sep-2010
Copyright © Siemens AG 2010
H CSG MR R&DBrian M. Dale, PhD
Fatty Liver Disease Progression
Incidence
10% - 24% overall
Up to 75% of obese
Primary FLD
NAFLD
NASH
Secondary FLD
Alcoholic
Hepatitis
Drug-induced
Surgically-induced
Page 5
Sep-2010
Copyright © Siemens AG 2010
H CSG MR R&DBrian M. Dale, PhD
Cirrhosis
Symptoms
Fatigue
Bleeding/brusing
Nausea
Weight loss
Ascites
Diagnosis
Liver biopsy
FibroTest
Irreversible
Prevent further damage
Liver transplant
Wikipedia
Page 6
Sep-2010
Copyright © Siemens AG 2010
H CSG MR R&DBrian M. Dale, PhD
How Can We Detect FLD Early?
Early Stage FLD
Treatable
Asymptomatic
Fat is present
MR Signal Characteristics
Short T1
Chemical shift 3.5 ppm
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Summary of Contents

Page 1 - Abdominal and Pelvic Imaging

1Copyright © Siemens AG 2010. All rights reserved.Emerging MRI Techniques for Abdominal and Pelvic Imaging Brian M. Dale, PhDPage 2Sep-2010Copyright ©

Page 2

2Page 7Sep-2010Copyright © Siemens AG 2010H CSG MR R&DBrian M. Dale, PhDSequence Overview3D spoiled steady state  T1 weighted Dual-echo In-phas

Page 3

3Page 13Sep-2010Copyright © Siemens AG 2010H CSG MR R&DBrian M. Dale, PhDRemaining LimitationsUnproven for early stage FLD No good gold standard

Page 4 - Automatically played

4Page 19Sep-2010Copyright © Siemens AG 2010H CSG MR R&DBrian M. Dale, PhDMRCPGuided The right choice when needed Your decisions are seamlessly in

Page 5

5Page 25Sep-2010Copyright © Siemens AG 2010H CSG MR R&DBrian M. Dale, PhD3D T2w TSEAcquire 3D isotropic  Reformat any planeLong echo train T2 de

Page 6

6Page 31Sep-2010Copyright © Siemens AG 2010H CSG MR R&DBrian M. Dale, PhDAcquisition TimeSagittal 3D (+ Recons)Ax, cor & sag 2DMean ± StDev 6

Page 7 - Ax 3D dual echo GRE w/wo Gad

7Page 37Sep-2010Copyright © Siemens AG 2010H CSG MR R&DBrian M. Dale, PhD3-plane localizerSingle plane 3D FSE T2wAx 3D dual echo GRE w/wo Gad“Fast

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